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In Vivo Cellular Molecular Imaging Center

Publications

Conference Presentations

Publications:

  • Peer-reviewed Scientific Articles

    1. Bhujwalla, Z.M., Artemov, D., Ballesteros, P., Cerdan, C., Gillies, R.J. and Solaiyappan, M. Combined vascular and extracellular pH imaging of solid tumors. NMR in Biomedicine, 15(2):114-119, 2002. Special Issue on Angiogenesis, Editor: Kevin Brindle.
    2. Pilatus, U., Aboagye, E., Artemov, D., Mori, N. and Bhujwalla, Z M. Real-Time measurements of cellular oxygen consumption, pH and energy metabolism using Nuclear Magnetic Resonance Spectroscopy. Magnetic Resonance in Medicine, 45, pp 749-755, 2001.
    3. Ackerstaff, E., Pflug, B.R., Nelson, J.B., and Bhujwalla, Z.M. Detection of Increased Choline Compounds with 1H NMR Spectroscopy following Malignant Transformation of Human Prostatic Epithelial Cells. Cancer Research, Vol. 61, pp 3599-3603, 2001.
    4. Artemov, D., Solaiyappan, M. and Bhujwalla, Z.M. Magnetic Resonance Pharmacoangiography to Detect and Predict Drug Delivery to Cancers by MR Imaging and Spectroscopy. Cancer Research, Vol 61, pp 3039-3044, 2001.
    5. Bhujwalla, Z.M., Artemov, D., Natarajan, K., Ackerstaff, E., and Solaiyappan, M. Vascular Differences Detected by MRI for Metastatic versus Nonmetastatic Breast and Prostate Cancer Xenografts. Neoplasia, Vol.3, pp 143-153, 2001. (Front cover)
    6. Semenza, G.L., Bedi, A., Bhujwalla, Z., Chiles, K., De Marzo, A., Feldser, D., Hilton, D., Laughner, E., Ravi, R., Simons, J., Zagzag, D., Zhong, H. Involvement of hypoxia-inducible factor 1 in tumor progression. Clinical Cancer Research, 6: 049 Suppl. S, 2000
    7. Pilatus, U., Ackerstaff, E., Artemov, D., Mori, N., Gillies, R.J., and Bhujwalla, Z.M. Imaging prostate cancer invasion with multi-nuclear magnetic resonance methods: The Metabolic Boyden Chamber. Neoplasia, Vol. 2, pp 273-279, 2000.
    8. Gillies, R.J., Bhujwalla, Z.M., Evelhoch, J., Garwood, M., Neeman, M., Robinson, S.P., Ronen, S.M., Sotak, C.H., van der Sanden, B. Applications of Magnetic Resonance in Model Systems I: Tumor Biology and Physiology. Neoplasia, 2(1):1-14, 2000. (Review article, peer- reviewed).
    9. Ravi, R., Mookerjee, B., Bhujwalla, Z.M., Hayes Sutter, C., Artemov, D., Zeng, Q., Dillehay, L.E., Madan, A., Semenza, G L. and Bedi, A. Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1a. Genes and Development, 14(1): 34-44, 2000.
    10. Artemov, D., Pilatus, U., Chou, S., Mori, N., Nelson, J.B., and Bhujwalla, Z.M. Dynamics of Prostate Cancer Cell Invasion Studied in vitro by NMR Microscopy. Magnetic Resonance in Medicine, 42:277-282, 1999.
    11. Raghunand, N., He, X., van Sluis, R., Mahoney, B., Baggett, B., Taylor, C.W., Paine-Murrieta, G., Roe, D., Bhujwalla, Z.M. and Gillies, R.J. Enhancement of chemotherapy by manipulation of tumour pH. British Journal of Cancer, 80: 1005-1011, 1999.
    12. Bhujwalla, Z.M., Aboagye, E.O., Gillies, R.J., Chacko, V.P., Mendola, C.E. and Backer, J.M. Nm23-transfected MDA-MB-435 human breast carcinoma cells form tumors with altered phospholipid metabolism and pH. A 31P NMR study In vivo and In vitro. Magnetic Resonance in Medicine, 41: 897-903, 1999 .
    13. van Sluis R., Bhujwalla Z.M., Raghunand N., Ballesteros P., Alvarez J., Cerdan S. and Gillies R.J. Imaging of extracellular pH of tumors using 1H MRSI. Magnetic Resonance in Medicine, 41: 743-750, 1999.
    14. Artemov, D., Revelon, G., Atalar, E., Bluemke, D.A., Bhujwalla, Z.M. and Zerhouni, E.A. Switchable Multicoil Array for MR Microimaging of Breast Lesions. Magnetic Resonance in Medicine, 41: 569-574, 1999.
    15. Raghunand N., Altbach M.I., van Sluis R., Baggett B., Taylor C.W., Bhujwalla Z.M. and Gillies R.J. Plasmalemmal pH-gradients in Drug-Sensitive and Drug-Resistant MCF-7 Human Breast Carcinoma Xenografts Measured by 31P MR Spectroscopy. Biochemical Pharmacology 57(3):309-12, 1999.
    16. Aboagye, E.O. and Bhujwalla, Z.M. Malignant Transformation Alters Membrane Phospholipid Metabolism of Human Mammary Epithelial Cells. Cancer Research, 59, 80-84, 1999.
    17. Aboagye, E.O., Dillehay, L.E., Bhujwalla, Z.M., Lee, D-J. The hypoxic cytotoxin tirapazamine induces acute changes in tumor energy metabolism and pH: A 31P Magnetic Resonance Spectroscopy Study. Radiation Oncology Investigations, 6: 249-254, 1998.
    18. Artemov, D., Bhujwalla, Z.M., Pilatus, U. and Glickson, J.D. Two-compartment model for determination of glycolytic rates of solid tumors by in vivo C-13 NMR spectroscopy. NMR in Biomedicine,11, 395-404, 1998.
    19. Aboagye, E., Artemov, D., Senter, P.D. and Bhujwalla, Z.M. Intratumoral Conversion of 5-Fluorocytosine to 5-Fluorouracil by Monoclonal Antibody-Cytosine Deaminase Conjugates: Noninvasive detection of prodrug activation by Magnetic Resonance Spectroscopy and Spectroscopic Imaging. Cancer Research, 58, 4075-4078, 1998.
    20. Bhujwalla, Z.M., McCoy, C.L., Glickson, J.D., Gillies, R.J. and Stubbs, M. Non-invasive measurements of intra- and extracellular spaces and pH of tumors, before and after 5-fluorouracil, by 31P MR Spectroscopy. British Journal of Cancer, 78, 606-611, 1998.
    21. Aboagye, E., Bhujwalla, Z.M., He, Q. and Glickson, J.D. Evaluation of Lactate as a 1H Nuclear Magnetic Resonance Spectroscopy Index for Noninvasive Prediction and Early Detection of Tumor Response to Radiation Therapy in EMT6 Tumors. Radiation Research, 150, 38-42, 1998.
    22. Aboagye, E., Bhujwalla, Z.M., Shungu, D.C. and Glickson, J.D. Detection of Tumor Response to Chemotherapy by 1H NMR Spectroscopy: Effect of 5-Fluorouracil on Lactate Levels in RIF-1 Tumors. Cancer Research, Vol.58: 1063-1067, 1998.
    23. Bhujwalla, Z.M. and Glickson, J.D. Detection of tumor response to radiation therapy by in vivo proton MR spectroscopy. Int. J. Radiat. Oncol. Biol. Phys., Vol.36: 635-639, 1996.
    24. He, Q., Bhujwalla, Z.M. and Glickson, J.D. Proton detection of choline and lactate in EMT6 tumors by spin-echo-enhanced selective multiple-quantum-coherence transfer. J.Mag. Res., Series B 112, 18-25,1996.
    25. Bhujwalla, Z.M., Shungu, D.C. and Glickson J.D. Effects of blood flow modifiers on tumor metabolism observed in vivo by proton spectroscopic imaging. Mag. Res. Med. 36: 204-211, 1996.
    26. Artemov, D., Bhujwalla, Z.M., Maxwell, R.J., Judson, I.R., Leach, M.O., Griffiths, J.R. and Glickson J.D. Pharmacokinetics of the 13C labelled anticancer agent temozolomide detected in vivo by selective cross polarization transfer. Mag. Res.Med. 34: 338-342, 1995.
    27. Artemov, D., Bhujwalla, Z.M. and Glickson J.D. Band Selective Heteronuclear Cross Polarization in Liquids. J. Mag. Res., Series B 107:1-3, 1995.
    28. He, Q., Bhujwalla, Z.M., Maxwell, R.J., Griffiths, J.R. and Glickson, J.D. Proton observation of the antineoplastic agent iproplatin in vivo by selective multiple quantum coherence transfer (Sel-MQC). Mag. Res. Med. 33:414-416, 1995.
    29. He Q., van Zijl P.C.M., Shungu D.C., Bhujwalla Z.M. and Glickson J.D. Single scan in vivo lactate editing with complete lipid and water suppression by selective multiple quantum coherence transfer (Sel-MQC) with application to tumors. J. Mag. Res., Series B 106: 203-211, 1995.
    30. .Artemov D., Bhujwalla Z.M. and Glickson J.D. In vivo selective measurement of 1-13C glucose metabolism in tumors by heteronuclear cross-polarization. Mag. Res. Med.33: 151-155, 1995.
    31. Bhujwalla Z.M., Shungu D.C., Chatham J.C., Wehrle J.P. and Glickson J.D. Glucose metabolism in RIF-1 tumors after reduction in blood flow: an in vivo 13C and 31P NMR study. Mag. Res. Med. 32: 303-309, 1994.
    32. Gillies R.J., Liu Z. and Bhujwalla Z.M. 31P MRS measurement of extracellular pH in tumors using 3-aminopropylphosphonate. Am. J. Physiol. 267( Cell Physiology 37): C195-C203, 1994.
    33. Stubbs, M., Bhujwalla, Z.M., Tozer, G.M., Rodrigues, L.M., Maxwell, R.J., Morgan, R., Howe, F.A. and Griffiths, J.R. An assessment of 31P MRS as a method of measuring pH in animal tumours. NMR in Biomedicine, Vol.5, 315-359, 1992.
    34. Shungu, D.C., Bhujwalla, Z.M., Wehrle, J.P. and Glickson, J.D. 1H NMR spectroscopic studies of subcutaneous tumors in mice: Effects of growth, chemotherapy and blood flow reduction. NMR in Biomedicine, Vol.5, 296-302, 1992.
    35. Shungu, D.C., Bhujwalla, Z.M., Li, Shi-Jiang, Rose, L.M., Wehrle, J.P. and Glickson, J.D. Determination of absolute phosphate metabolite concentrations in RIF-1 tumors in vivo by 31P-1H-2H NMR spectroscop y using water as an internal intensity reference. Mag. Res. in Med., Vol. 28, pp 105-121, 1992.
    36. Bhujwalla, Z.M., Blackband, S.B., Wehrle, J.P. and Glickson, J.D. Spatial heterogeneity of the metabolic response of RIF-1 tumours to a vasoactive agent evaluated in vivo by 1-dimensional 31P chemical shift imaging. Mag. Res . in Med., Vol.26, pp 308-312, 1992.
    37. Bhujwalla, Z.M., Constantinidis, I.C., Chatham, J.C., Wehrle, J.P. and Glickson, J.D. Energy metabolism, pH changes and lactate production in RIF-1 tumors following intratumoral injection of glucose. Int. J. Radiat. Oncol. Biol. Phys., Vol.22, No.1, pp 95-101, 1992.
    38. Bhujwalla, Z.M., Blackband, S.J., Wehrle, J.P., Grossman, S., Eller, S. and Glickson, J.D. Metabolic heterogeneity in RIF-1 tumours detected in vivo by 31P NMR spectroscopy. NMR in Biomedicine, Vol.3, No.5, pp 233-238, 1990.
    39. Bhujwalla, Z.M., Tozer, G.M., Field, S.B., Proctor, E.P., Busza, A. and Williams, S.R. The combined measurement of blood flow and metabolism in RIF-1 tumours in vivo: A study using H2 flow and 31P NMR spectroscopy. NMR in Biomedicine, Vol.3, No.4, pp 178-183, 1990.
    40. Bhujwalla, Z.M., Tozer, G.M., Field, S.B., Maxwell, R.J. and Griffiths, J.R. Energy metabolism of RIF-1 tumours following hydralazine. Radiotherapy and Oncology, Vol. 19, No.3, pp 281-291, 1990.
    41. Tozer, Gillian M., Bhujwalla, Zaver M., Griffiths, John R. and Maxwell, Ross J. Phosphorus-31 magnetic resonance spectroscopy and blood perfusion of the RIF-1 tumour following X-irradiation. Int. J. Radiat. Oncol. Biol. Phys., Vol. 16, No.1, pp 155-164, 1989.

     

  • Invited Reviews

    1. Bhujwalla, Z.M., Artemov, D., Solaiyappan, M. Insights into Tumor Vascularization using Magnetic Resonance Imaging and Spectroscopy. Experimental Oncology, Vol. 22, pp 3-7, 2000
    2. Bhujwalla, Z.M., Artemov, D., Glockner, J. Tumor angiogenesis, vascularization and contrast enhanced MRI. Topics in Magnetic Resonance Imaging, 10(2):92-103, 1999.
    3. Griffiths, J.R., Bhujwalla, Z.M., Coombes, R.C., Maxwell, R.J., Midwood, C.J., Morgan, R.J., Nias, A.H.W., Perry, P., Prior, M., Prysor-Jones, R.A., Rodrigues, L.M., Stubbs, M. and Tozer, G.M. Monitoring cancer therapy by NMR spectroscopy. Annals of the New York Academy of Sciences, Vol. 508, pp 183-199, 1987.

     

  • Papers presented at Symposia and Published in Journals or Books

    1. Bhujwalla, Z.M., Artemov, D., Aboagye, E., Ackerstaff, E., Gillies, R.J., Natarajan, K. and Solaiyappan, M. The Physiological Environment in Cancer Vascularization, Invasion and Metastasis. Novartis Foundation Symposium 240. Published by John Wiley and Sons, October 2001 (No. 0471 49959 5).
    2. Semenza, G. L., Artemov, D., Bedi, A., Bhujwalla, Z.M., Chiles, K., Feldser, D., Laughner, E., Ravi R., Simons, J. and Zhong, H. The Metabolism of Tumours: 70 years later. Novartis Foundation Symposium 240. Published by John Wiley and Sons, October 2001 (No. 0471 49959 5).
    3. Aboagye, E., Mori, N., and Bhujwalla, Z.M. Effect of Malignant Transformation on lactate levels of Human Mammary Epithelial Cells. Advances in Enzyme Regulation, Vol.41, pp 251-260, 2001.
    4. Natarajan, K., Mori, N., Artemov, D., Aboagye, E.O., Chacko, V. P. and Bhujwalla, Z.M. Phospholipid profiles of invasive human breast cancer cells are altered towards a less invasive phospholipid profile by the anti-inflammatory agent indomethacin. Advances in Enzyme Regulation, Vol. 40, pp 271-284, 2000.

     

  • Book Chapter

    • Bhujwalla Z.M., Shungu D.C., He Q., Wehrle J.P. and Glickson J.D. MR studies of tumors: relationshipbetween blood flow, metabolism and physiology. in: NMR in Physiology and Biomedicine, pp 311-328, ed. R.J. Gillies, Academic Press, 1994.

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Presentations at Meetings Published in Conference Proceedings:

Peer Reviewed Abstracts
Over 100 peer reviewed abstracts have been presented as talks or posters at national and international meetings held by the International Society of Magnetic Resonance in Medicine, American Association of Cancer Research, Radiation Research Society, Chemical Modifiers in Cancer Treatment.

 

  1. Glunde, K., Ackerstaff, E., Natarajan, K., Artemov, D., Bhujwalla, Z.M. Indomethacin Alters Phospholipid Metabolism in a pH-Independent Manner in Living Breast Cancer Cells. ISMRM International Society for Magnetic Resonance in Medicine, 10th Scientific Meeting & Exhibition, Honululu, Hawai'i, USA, May 18-24, 2002.
  2. Glunde, K., Chacko, V.P., Bhujwalla, Z.M. Mechanisms of Indomethacin Induced Alterations in Phospholipid Metabolism in Human Mammary Epithelial Cells Studied by 1H and 13C NMR Spectroscopy. ISMRM International Society for Magnetic Resonance in Medicine, 10th Scientific Meeting & Exhibition, Honululu, Hawai'i, USA, May 18-24, 2002.
  3. Dafni, H., Benjamin, L.E., Bhujwalla, Z.M., Neeman, M. MRI detection of lymphatic drain in VEGF over-expressing tumors following intravenous administration of macromolecular contrast material. ISMRM International Society for Magnetic Resonance in Medicine, 10th Scientific Meeting & Exhibition, Honululu, Hawai'i, USA, May 18-24, 2002.
  4. Jacobs, M., Barker, P.B., Bluemke, D.A., Arnold, C., Maranto, C., Bhujwalla, Z.M. Proton MR Spectroscopic Imaging of Human Breast Cancer. ISMRM International Society for Magnetic Resonance in Medicine, 10th Scientific Meeting & Exhibition, Honululu, Hawai'i, USA, May 18-24, 2002.
  5. Artemov, D., Bhujwalla, Z.M. On-line Monitoring of Contrast Agent Arterial Input Function in Mouse MRI. ISMRM International Society for Magnetic Resonance in Medicine, 10th Scientific Meeting & Exhibition, Honululu, Hawai'i, USA, May 18-24, 2002.
  6. Artemov, D., Mori, N., Ravi, R., Bhujwalla, Z.M. MR Molecular Imaging of Her-2/Neu Receptor with Gd based targeted ContrastAgent. ISMRM International Society for Magnetic Resonance in Medicine, 10th Scientific Meeting & Exhibition, Honululu, Hawai'i, USA, May 18-24, 2002.
  7. Ackerstaff, E., Artemov, D., Gillies, R.J., Bhujwalla, Z.M. Human Umbilical Vein Endothelial Cells Promote Invasion of PC-3 under Hypoxia. ISMRM International Society for Magnetic Resonance in Medicine, 10th Scientific Meeting & Exhibition, Honululu, Hawai'i, USA, May 18-24, 2002.
  8. Raman, V., Artemov, D., Mironchik, Y., Bhujwalla, Z.M. Combined and co-registered MRI, MRSI and optical imaging characterization of tumor vascularization, metabolism and hypoxia. ISMRM International Society for Magnetic Resonance in Medicine, 10th Scientific Meeting & Exhibition, Honululu, Hawai'i, USA, May 18-24, 2002.
  9. Bhujwalla, Z.M., Artemov, D., Solaiyappan, M. Combined Vascular and Metabolic characterization of Orthotopically implanted Prostate Cancer Xenografts. ISMRM International Society for Magnetic Resonance in Medicine, 10th Scientific Meeting & Exhibition, Honululu, Hawai'i, USA, May 18-24, 2002.
  10. Ackerstaff, E., Artemov, D., Bhujwalla, Z.M. Indomethacin reduces the invasion of the human breast cancer cell lineMDA-MB-435. ISMRM International Society for Magnetic Resonance in Medicine, 10th Scientific Meeting & Exhibition, Honululu, Hawai'i, USA, May 18-24, 2002.
  11. Mori, N., Delsite, R., Natarajan, K., Singh, K.K., Bhujwalla, Z.M. Loss of p53 function in Colon Cancer Cells results in increased Phosphocholine and Total Choline. ISMRM International Society for Magnetic Resonance in Medicine, 10th Scientific Meeting & Exhibition, Honululu, Hawai'i, USA, May 18-24, 2002.
  12. Mori, N., Delsite, R., Natarajan, K., Chacko, V.P., Artemov,D., Singh, K.K., Bhujwalla, Z.M. Mitochondrial DNA depletion produces changes in choline phospholipids in 1H NMR spectra. ISMRM International Society for Magnetic Resonance in Medicine, 10th Scientific Meeting & Exhibition, Honululu, Hawai'i, USA, May 18-24, 2002.
  13. Raman, V., Artemov, D., Mironchik, Y., Bhujwalla, Z.M. Combined Magnetic Resonance and Optical Imaging Characterization of the Tumor Microenvironment. 93nd Annual Meeting of the American Association for Cancer Research, April 6-10, San Francisco, CA, 2002.
  14. Glunde, K., Guggino, S., Ichikawa, Y., Bhujwalla, Z.M. Altered Lysosomal Trafficking in Human Breast Cancer Cells during Extracellular Acidosis. 93nd Annual Meeting of the American Association for Cancer Research, April 6-10, San Francisco, CA, 2002.
  15. Gullapalli, R.P., Dibiase, S.J., Harrison, G., Melera, P., Jelovic, D., Franklin, R., Bhujwalla, Z.M., Artemov, D., Brodie, A. Monitoring of Metabolites Using 1H and 31P NMR and Correlation with LnCAP Tumor Volume Changes Following Radiation in Male SCID Mice. 93nd Annual Meeting of the American Association for Cancer Research, April 6-10, San Francisco, CA, 2002.
  16. Bhujwalla, Z.M., Artemov, D., Natarajan, K., Kristjansen, P.E.G. Anti-Angiogenic agent TNP-470 Significantly Decreases Permeable Regions. 9th Scientific Meeting and Exhibition of the International Society of Magnetic Resonance in Medicine, ISMRM-ESMRB Joint Annual Meeting, Glasgow, 21-27 April, 2001.
  17. Ackerstaff, E., Pflug, B.R., Nelson, J.B. and Bhujwalla, Z.M. Increased Lactate characterizes Malignant Transformation in Human Prostate Cancer Cells. 9th Scientific Meeting and Exhibition of the International Society of Magnetic Resonance in Medicine, ISMRM-ESMRB Joint Annual Meeting, Glasgow, 21-27 April, 2001.
  18. Natarajan, K., Mori, N., Artemov, D. and Bhujwalla, Z.M. Enhanced expression of metastasis suppressor gene may play a role in phospholipid changes in breast cancer cells following treatment with an anti-inflammatory agent indomethacin. 9th Scientific Meeting and Exhibition of the International Society of Magnetic Resonance in Medicine, ISMRM-ESMRB Joint Annual Meeting, Glasgow, 21-27 April, 2001.
  19. Natarajan, K., Artemov, D., Bhujwalla, Z.M. Changes in Vasculature Detected in a Breast Cancer Model Following Treatment with an Anti-inflammatory Agent. 9th Scientific Meeting and Exhibition of the International Society of Magnetic Resonance in Medicine, ISMRM-ESMRB Joint Annual Meeting, Glasgow, 21-27 April, 2001.
  20. Mori, N., Natarajan, K., Chacko, V.P., Artemov, D. and Bhujwalla, Z.M. Malignant cells can influence the phospholipid phenotype of Human Vascular Endothelial cells. 9th Scientific Meeting and Exhibition of the International Society of Magnetic Resonance in Medicine, ISMRM-ESMRB Joint Annual Meeting, Glasgow, 21-27 April, 2001.
  21. Jacobs, M.A., Bhujwalla, Z.M., Bluemke, D., Marano, C. and Barker,, P.B. A Model to Differentiate Benign from Malignant Breast tumors using Multiparametric MRI with Histological Correlates. 9th Scientific Meeting and Exhibition of the International Society of Magnetic Resonance in Medicine, ISMRM-ESMRB Joint Annual Meeting, Glasgow, 21-27 April, 2001.
  22. Bhujwalla, Z.M., Artemov, D., Ballesteros, P., Cerdan, S., Gillies, R.J. and Solaiyappan, M. Identifying High 'Metastatic Risk' Vascular and Physiological Regions in Solid Tumors. 9th Scientific Meeting and Exhibition of the International Society of Magnetic Resonance in Medicine, ISMRM-ESMRB Joint Annual Meeting, Glasgow, 21-27 April, 2001.
  23. Ackerstaff, E., Artemov, D., Gillies, R.J. and Bhujwalla, Z.M. Endothelial Cells promote Cancer Cell Invasion under Hypoxia. 9th Scientific Meeting and Exhibition of the International Society of Magnetic Resonance in Medicine, ISMRM-ESMRB Joint Annual Meeting, Glasgow, 21-27 April, 2001.
  24. Artemov, D., Mori, N., Ravi, R. and Bhujwalla, Z.M. MR Molecular Imaging of Her-2/Neu Receptor with targeted Nanoparticles. 9th Scientific Meeting and Exhibition of the International Society of Magnetic Resonance in Medicine, ISMRM-ESMRB Joint Annual Meeting, Glasgow, 21-27 April, 2001.
  25. Glunde, K., Ackerstaff, E., Natarajan, K., Artemov, D. and Bhujwalla, Z.M. Impact of Indomethacin on Phospholipid Metabolism in Malignant Human Mammary Epithelial Cells: 1H and 31P NMR Spectroscopic Study of Viable Cells. 9th Scientific Meeting and Exhibition of the International Society of Magnetic Resonance in Medicine, ISMRM-ESMRB Joint Annual Meeting, Glasgow, 21-27 April, 2001.
  26. Ackerstaff, E., Artemov, D., Gillies, R.J. and Bhujwalla, Z.M. Evaluation of Breast Cancer Cell Invasion with the ‘Metabolic Boyden Chamber. 9th Scientific Meeting and Exhibition of the International Society of Magnetic Resonance in Medicine, ISMRM-ESMRB Joint Annual Meeting, Glasgow, 21-27 April, 2001.
  27. Schornak, P.A., McLoyde, R., Bhujwalla, Z.M., Gillies, R.J. and Witte, M.H. Imaging of Lymphatic Anatomy and Function in Mouse Adults and Pups with Gd-albumin. 9th Scientific Meeting and Exhibition of the International Society of Magnetic Resonance in Medicine, ISMRM-ESMRB Joint Annual Meeting, Glasgow, 21-27 April, 2001.
  28. Kristjansen, P.E.G., Artemov, D., Kragh, M., Horsman, M.R. and Bhujwalla, Z.M. Early Changes in Vascular Physiology of Tumors during continuous Anti-Angiogenic Therapy. 92nd Annual Meeting of the American Association for Cancer Research, March 24-28, New Orleans, LA, 2001.
  29. Natarajan, K., Mori, N., Artemov, D. and Bhujwalla, Z.M. NMR Spectroscopic Detection of Response of Normal and Malignant Human Mammary Epithelial Cells to Anti-Inflammatory Agents. 91st Annual Meeting of the American Association of Cancer Research, San Francisco, April 1-5, 2000.
  30. Delsite, R.L., Natarajan, K., Bhujwalla, Z.M. and Singh, K. Mitochondrial DNA Depletion alters the metabolic profile of HeLa Cervical Carcinoma Cells. 91st Annual Meeting of the American Association of Cancer Research, San Francisco, April 1-5, 2000.
  31. Bhujwalla, Z.M., Artemov, D., Solaiyappan, M. Vascular Characterization of Human Breast Cancer and Prostate Cancer Models. 8th Scientific Meeting and Exhibition of the International Society of Magnetic Resonance in Medicine, Denver, Colorado, 1-7 April 2000.
  32. Mori, N., Natarajan, K., Chacko, V.P., Artemov, D. and Bhujwalla, Z.M. The Effect of an Anti-Inflammatory Agent Indomethacin on Human Vascular Endothelial Cell Phospholipids. 8th Scientific Meeting and Exhibition of the International Society of Magnetic Resonance in Medicine, Denver, Colorado, 1-7 April 2000.
  33. Ackerstaff, E., Pilatus, U., Artemov, D., Mori, N., Gillies, R.J. and Bhujwalla, Z.M. Multinuclear Magnetic Resonance Imaging and Spectroscopy of Prostate Cancer Cell Invasion. 8th Scientific Meeting and Exhibition of the International Society of Magnetic Resonance in Medicine, Denver, Colorado, 1-7 April 2000.
  34. Ackerstaff, E., Pflug, B. R., Nelson, J. B., Bhujwalla, Z.M. Alterations in Choline Compounds - A marker for the Malignant Phenotype in Human Prostate Cancer Cells. 8th Scientific Meeting and Exhibition of the International Society of Magnetic Resonance in Medicine, Denver, Colorado, 1-7 April 2000.
  35. Artemov, D., Magee, C., Abraham, S., Bhujwalla, Z.M. Geschwind, J.F. MRI Assessment of Chemoembolization of Liver Tumors in a Rabbit Model. 8th Scientific Meeting and Exhibition of the International Society of Magnetic Resonance in Medicine, Denver, Colorado, 1-7 April 2000.
  36. Artemov, D., Solaiyappan, M., Neeman, M. and Bhujwalla, Z.M. Tracking the Interstitial Movement of a Macromolecular Contrast Agent. 8th Scientific Meeting and Exhibition of the International Society of Magnetic Resonance in Medicine, Denver, Colorado, 1-7 April 2000.
  37. Bhujwalla, Z.M. and Artemov, D. Combined Proton Spectroscopic and Vascular Imaging of Prostate Cancer Models. 8th Scientific Meeting and Exhibition of the International Society of Magnetic Resonance in Medicine, Denver, Colorado, 1-7 April 2000.
  38. Natarajan, K., Delsite, R., Artemov, D., Singh, K.K. and Bhujwalla, Z.M. NMR Spectroscopic Studies on Mitochondrial Genome Depleted Cervical Carcinoma Cells. 8th Scientific Meeting and Exhibition of the International Society of Magnetic Resonance in Medicine, Denver, Colorado, 1-7 April 2000.
  39. Natarajan, K., Mori, N., Artemov, D. and Bhujwalla, Z.M. Cyclooxygenase Inhibition and its Role in the lH NMR Phospholipid Profiles of Human Mammary Epithelial Cells. 8th Scientific Meeting and Exhibition of the International Society of Magnetic Resonance in Medicine, Denver, Colorado, 1-7 April 2000.
  40. Pomper, M.G., Bhujwalla, Z.M., Artemov, D., Vaquero, J.J., Lee, L.A., Dang, C.V., Seidel, J. and Green M.V. Measurement of 18F Fluorodeoxyglucose Liver Uptake in a c-Myc Transgenic Mouse with positron Projection Imaging: A Feasibility Study. High Resolution Imaging in Small Animals with PET, MR and other modalities. Amsterdam, Sept. 27-29, 1999.
  41. Aboagye, E.O., Bhujwalla, Z.M. Characterization of lactate in normal and malignant Human mammary epithelial cells. 7th Scientific Meeting and Exhibition of the International Society of Magnetic Resonance in Medicine, Philadelphia, May 1999.
  42. Bhujwalla, Z.M., Artemov, D., Solaiyappan, M., Mao, D., Backer, J.P. Comparison of vascular volume and permeability for tumors derived from metastatic human breast cancer cells with and without the metastasis suppressor gene nm23. 7th Scientific Meeting and Exhibition of the International Society of Magnetic Resonance in Medicine, Philadelphia, May 1999.
  43. Bhujwalla, Z.M., Natarajan, K., Aboagye, E.O., Mori, N., Artemov, D., Pilatus, U., Chacko, V.P. The anti-inflammatory agent indomethacin reduces the malignant phospholipid phenotype of metastatic human breast cancer cells. 7th Scientific Meeting and Exhibition of the International Society of Magnetic Resonance in Medicine, Philadelphia, May 1999.
  44. Artemov, D., Bhujwalla, Z.M. Drug delivery to tumors: Potential of MR for Measurement and prediction. 7th Scientific Meeting and Exhibition of the International Society of Magnetic Resonance in Medicine, Philadelphia, May 1999.
  45. Pilatus, U., Ackerstaff, E.A., Artemov, D., Mori, N., Gillies, R.J., Bhujwalla, Z.M. Metabolic Boyden chamber detects significant differences in invasion for metastatic and nonmetastatic prostate cancer cells. 7th Scientific Meeting and Exhibition of the International Society of Magnetic Resonance in Medicine, Philadelphia, May 1999.
  46. Alvarez-Perez, J., van Sluis, R., Raghunand, N., Bhujwalla, Z.M., Cerdan, S., Gillies, R.J., Ballesteros, P. pH heterogeneity in spheroids by 1H MRSI microscopy. 7th Scientific Meeting and Exhibition of the International Society of Magnetic Resonance in Medicine, Philadelphia, May 1999.
  47. Portnow, J., Artemov, D., Eller, S. Solaiyappan, M., Grossman, S.A., Bhujwalla, Z.M. Mapping white matter tracts involved with the dissemination of primary brain tumors: A preliminary investigation in rats using intracerebral albumin-(Gd-DTPA) with MRI. 7th Scientific Meeting and Exhibition of the International Society of Magnetic Resonance in Medicine, Philadelphia, May 1999.
  48. Artemov, D., Solaiyappan, M., Bhujwalla, Z.M. 3-dimensional interactive registration of MR images and histological data. 7th Scientific Meeting and Exhibition of the International Society of Magnetic Resonance in Medicine, Philadelphia, May 1999.
  49. Aboagye, E.O., Mori, N., Pilatus, U., Artemov, D., Chacko, V.P., Bhujwalla, Z.M. Alteration of phospholipid metabolism in human breast cancer cells by the anti-inflammatory agent indomethacin. 90th Annual Meeting of the American Association for Cancer Research, Philadelphia, 1999.
  50. Aboagye, E.O., Dillehay, L.E., Bhujwalla, Z.M., Lee, J.D. Effects of tirapazamine on the energy metabolism of RIF-1 tumors. 1998, Session II-31. 9th International Conference on Chemical Modifiers of Cancer Treatment, Clearwater, 1998.
  51. Aboagye, E.O., Bhujwalla, Z.M., Gillies, R.J., Mendola, C.E., Backer, J.M. Nm23-Transfected MDA-MB-435 human breast carcinoma cells form tumors with altered phospholipid metabolism and pH. A 31P NMR study in vivo and in vitro. 89th Annual Meeting of the American Association for Cancer Research, New Orleans, 1998.
  52. Aboagye, E.O., Bhujwalla, Z.M. The Choline phospholipid resonances as tumor markers in mammary epithelial cells: underlying mechanisms. 6th Annual Meeting, International Society for Magnetic Resonance in Medicine, Sydney, April, 1998.
  53. Aboagye, E.O., Artemov, A., Senter, P.D., Bhujwalla, Z.M. Tumor selective drug activation by monoclonal antibody-cytosine deaminase conjugates monitored by magnetic resonance spectroscopy and spectroscopic imaging. 6th Annual Meeting, International Society for Magnetic Resonance in Medicine, Sydney, April, 1998.
  54. Pilatus, U., Aboagye, E.O., Artemov, D., Bhujwalla, Z.M. An on-line 19F NMR oxygen consumption meter compatible with simultaneous metabolic and physiological measurements of perfused cells. 6th Annual Meeting, International Society of Magnetic Resonance in Medicine, Sydney, April,, 1998.
  55. Pilatus, U., Aboagye, E.O., Artemov, D., Bhujwalla, Z.M. Characterization of physiological changes and metabolic changes in the tumor environment following g-irradiation. 6th Annual Meeting, International Society for Magnetic Resonance in Medicine, Sydney, April, 1998.
  56. Artemov, D., Revelon, G., Atalar, E., Bluemke, D.A., Bhujwalla, Z.M., Zerhouni, E.A. Switchable 12 Element Coil Array for MR Microimaging of Breast Lesions. 6th Annual Meeting, International Society for Magnetic Resonance in Medicine, Sydney, April, 1998.
  57. Bhujwalla, Z.M., Aboagye, E.O., Gillies, R.J., Mendola, C.E., Barker, J.M. Nm23-transfected MDA-MB-435 human breast carcinoma cells form tumors with altered phospholipid metabolism and pH. A 31P NMR study in vivo and in vitro. 6th Annual Meeting, International Society for Magnetic Resonance in Medicine, Sydney, April, 1998.
  58. Revelon, G., Artemov, D., Bhujwalla, Z.M., Atalar, E., Brem, R., Zerhouni, E.A., Bluemke, D.A. In vivo Microscopic MR Imaging of Breast Lesions. 6th Annual Meeting, International Society for Magnetic Resonance in Medicine, Sydney, April-May 1998.
  59. van Sluis, R, Bhujwalla, Z.M., Raghunand, N., Ballesteros, P., Alvarez, J., Cerdan, S., Gillies, R.J. Imaging of extracellular pH using 1H MRSI. 6th Annual Meeting, International Society for Magnetic Resonance in Medicine, Sydney, April, 1998.
  60. Raghunand, N., He, X., van Sluis, R. Bhujwalla, Z.M., Gillies, R.J. 31P MRS measurements of intracellular and extracellular pH in MCF-7 human breast carcinoma xenografts in SCID mice subjected to dietary alkaline loads. 6th Annual Meeting, International Society for Magnetic Resonance in Medicine, Sydney, April, 1998
  61. Raghunand, N., He, X., van Sluis, R., Bhujwalla, Z.M., Gillies, R.J. Plasmelemmal pH-gradients in drug sensitive and drug-resistant MCF-7 human breast carcinoma tumors measured by 31P MRS. 6th Annual Meeting, International Society for Magnetic Resonance in Medicine, Sydney, April, 1998.
  62. Solaiyappan, M., Artemov, D. and Bhujwalla, Z.M. Functional Correlation of 3-Dimensional MRI Maps of Tumor Vascular Volume and Permeability with 3-Dimensional Histological Morphology. 6th Annual Meeting, International Society for Magnetic Resonance in Medicine, Sydney, April-May 1998.
  63. Bhujwalla, Z.M., Aboagye, E.O., Mori, N., Chacko, V.P., Artemov, D. and Pilatus, U. The anti-inflammatory agent indomethacin increases phosphodiester levels in human breast cancer cells. ISMRM Workshop on Magnetic Resonance in Exp. and Clinical Cancer Research, St. Louis, Missouri, 1998.
  64. Aboagye, E.O., He, Q., Glickson, J.D., Bhujwalla, Z.M. Response of EMT6 mammary adenocarcinoma to radiation therapy detected by 1H MRS. 5th Annual Meeting, International Society for Magnetic Resonance in Medicine, Vancouver, April, 1997.
  65. Artemov, D., Bhujwalla, Z.M. 3-dimensional MRI quantitation of tumor vascular volume and permeability. 5th Annual Meeting, International Society of Magnetic Resonance in Medicine, Vancouver, April, 1997.
  66. Artemov, D., Pilatus, U., Mori, N., Bhujwalla, Z.M. NMR microscopy of breast cancer cell invasion. 5th Annual Meeting, International Society of Magnetic Resonance in Medicine, Vancouver, April 1997.
  67. Aboagye, E.O., Shungu, D.C., Glickson, J.D., Bhujwalla, Z.M. 1H MRS of RIF-1 fibrosarcoma tumors in response to 5-fluoruracil. 5th Annual Meeting, International Society of Magnetic Resonance in Medicine, Vancouver, April, 1997.
  68. Raghunand, N., Altbach, M.I., Bhujwalla, Z.M., Gillies, R.J. Extracellular pH excursions in drug-sensitive and drug-resistant MCF-7 human breast carcinoma cells: a 31P MRS study. 5th Annual Meeting, International Society of Magnetic Resonance in Medicine, Vancouver, April, 1997.
  69. Pilatus, U., Artemov, D., Bhujwalla, Z.M. Multinuclear NMR studies of the dependence of drug uptake on the physiological environment. 5th Annual Meeting, International Society of Magnetic Resonance in Medicine, Vancouver, April, 1997.
  70. Gillies, R.J., Raghunand, N., Bhujwalla, Z.M., Ballesteros, P., Alvarez, J., Cerdan, S. Measurement of extracellular pH in tumors by 1H MRSI. 5th Annual Meeting, International Society of Magnetic Resonance in Medicine, Vancouver, April, 1997.
  71. Pilatus, U., Artemov, D., Gillies, J., Bhujwalla, Z.M. The Metabolic Boyden chamber: A dynamic cancer cell invasion assay compatible with multinuclear NMR measurements of cellular physiology and metabolism. 5th Annual Meeting, International Society of Magnetic Resonance in Medicine, Vancouver, April, 1997.
  72. Artemov, D., Bhujwalla, Z.M., Glickson, J.D. Effect of drug infusion on 13C lipid signal of tumors in vivo. Experimental NMR Conference, Asilomar, 1996.
  73. Bhujwalla, Z.M., Glockner, J. F., Artemov, D., Glickson, J.D. Magnetic Resonance Imaging (MRI) of tumor vascularization and permeability of metastatic human breast cancer and non-metastatic rodent fibrosarcoma lines. 87th Meeting of the American Association of Cancer Research, Washington D.C., 1996.
  74. Artemov, D., Bhujwalla, Z.M., Pilatus, U., Aboagye, E.O., Maxwell, R.J., Griffiths, J.R., Glickson, J.D. Effect of drug infusion on 13C lipid signal of tumors in vivo. 4th Annual Meeting, International Society for Magnetic Resonance in Medicine, New York, April, 1996.
  75. Maxwell, R.J., Artemov, D., Bhujwalla, Z.M., Glickson, J.D., Griffiths, J.R., Leach, M.O., Judson, L.R., Wilman, D.E.V. Measurement of clearance and metabolism of the anticancer agent, trimelamol, in murine tumors by 13C - {1H} cross-polarization MRS. 4th Annual Meeting, International Society for Magnetic Resonance in Medicine, New York, April, 1996.
  76. Pilatus, U., Bhujwalla, Z.M., Glickson, J.D. 1H and 31P NMR studies of radiation-induced changes in metabolism of RIF-1 cells using a monolayer perfusion system. 4th Annual Meeting, International Society for Magnetic Resonance in Medicine, New York, April, 1996.
  77. Raghunand, N., Aiken, N.R., Bhujwalla, Z.M., Gillies, R.J. Measurement of extracellular pH in vivo using 3-aminopropylphosphonaste: Deconvolution of T2* effects. 4th Annual Meeting, International Society for Magnetic Resonance in Medicine, New York, April, 1996.
  78. Bhujwalla, Z.M., Glockner, J.F., Artemov, D., Glickson, D. Magnetic Resonance imaging of tumor vascular volume and permeability of metastatic human breast cancer and non-metastatic rodent fibrosarcoma lines. 4th Annual Meeting, International Society for Magnetic Resonance in Medicine, New York, April, 1996.
  79. Bhujwalla, Z.M., Shungu, D., Constantinidis, I., Chatham, J.C., Artemov, D., Wehrle, J.P., Glickson, J.D. Multinuclear magnetic resonance studies of metabolic and physiological characteristics of tumors. Advances in Physiological Chemistry by In Vivo NMR, A Workshop Presented by the Society for Magnetic Resonance in Medicine, Marine Biological Institute, Woods Hole, MA. March 22-24, 1995.
  80. Bhujwalla, Z.M., Glickson, J.D, Changes in proton spectroscopic images of in vivo tumors following gamma irradiation. Joint Meeting and Twelfth Annual Meeting, Society of Magnetic Resonance in Medicine and European Society for Magnetic Resonance in Medicine and Biology, Nice, August 1995: p 1683.
  81. Artemov, D., Pilatus, U., Bhujwalla, Z.M., Glickson, J.D. NMR spectroscopy of glucose metabolism in tumors. Joint Meeting and Twelfth Annual Meeting, Society of Magnetic Resonance in Medicine and European Society for Magnetic Resonance in Medicine and Biology, Nice, August 1995: p 1673.
  82. Artemov, D., Bhujwalla, Z.M., Glickson, J.D. In vivo imaging of glucose and lactate distribution in tumors. Joint Meeting and Twelfth Annual Meeting, Society of Magnetic Resonance in Medicine and European Society for Magnetic Resonance in Medicine and Biology, Nice, August 1995: p 66.
  83. Bhujwalla, Z.M., Glickson, J.D., Gillies, R.J. Non-invasive estimation of tumor intracellular and extracellular space and pH before and after 5-Fluorouracil by 31P NMR spectroscopy. Joint Meeting and Twelfth Annual Meeting, Society of Magnetic Resonance in Medicine and European Society for Magnetic Resonance in Medicine and Biology, Nice, August, 1995: p 68.
  84. Gillies, R.J., Raghunand, N., Bhujwalla, Z.M., Glickson, J.D., Stubbs, M., Griffiths, J.R. Measurement of extracellular pH in vivo using 31P MRS of 3-Aminopropylphosphonate. Joint Meeting and Twelfth Annual Meeting, Society of Magnetic Resonance in Medicine and European Society for Magnetic Resonance in Medicine and Biology, Nice, August 1995: p 1674.
  85. Artemov, D., Bhujwalla, Z.M., Glickson, J.D. In vivo imaging of uniformly labeled 13C glucose in tumors. 3rd International Conference on Magnetic Resonance Microscopy, Wurzburg, Germany, August 27-31, 1995.
  86. Bhujwalla, Z.M., Glickson, J.D. Changes in localized 1H NMR tumor spectra following 20 Gy g-Irradiation. 10th International Congress of Radiation Research, Wurzburg, Germany, August 27-31, 1995.
  87. Bhujwalla, Z.M., Glickson, J.D. MR imaging of tumor vascularization. Second Annual Meeting, Society of Magnetic Resonance, San Francisco, August 1994: p 283.
  88. Artemov, D., Bhujwalla, Z.M., Glickson, JD. In vivo selective measurement of {1-13C}-glucose metabolism in tumors by heteronuclear cross polarization. Second Annual Meeting, Society of Magnetic Resonance, San Francisco, August 1994: p 453.
  89. He, Q., Bhujwalla, Z.M., Maxwell, R.J., Glickson, J.D. Proton observation of the antineoplastic agent iproplatin in vivo by selective multiple quantum coherence transfer (Sel-MQC). Second Annual Meeting, Society of Magnetic Resonance, San Francisco, August 1994: p 456.
  90. Shungu, D.C., Bhujwalla, Z.M., Glickson. J.D. In vivo 1H MRS detection of RIF-1 tumor response to 5FU chemotheraphy. Second Annual Meeting, Society of Magnetic Resonance, San Francisco, August 1994: p 1329.
  91. Artemov, D., Bhujwalla, Z.M., Maxwell, R.J., Griffiths, J.R., Glickson, J.D. Pharmacokinetics of the 13C labeled anticancer agent temozolomide detected in vivo by selective cross polarization transfer. Second Annual Meeting, Society of Magnetic Resonance in Medicine, San Francisco, August 1994: p 1344.
  92. Bhujwalla, Z.M., Shungu, D.C., He, Q., Wehrle, J.P. and Glickson, J.D. Nicotinamide induced changes in tumor choline compounds, detected in vivo by localized 2-dimensional 1H NMR spectroscopy. The 8th International Conference on Chemical Modifiers in the Treatment of Cancer, Kyoto, Japan, June 1993.
  93. Bhujwalla, Z.M., Shungu, D.C., Glickson, J.D. Susceptibility maps of tumors and their relationship to histopathological characteristics and flow. 12th Annual Scientific Meeting and Exhibition, Society of Magnetic Resonance in Medicine, New York, August 1993: p 142.
  94. He, Q., van Zijl, P.C.M., Shungu, D.C., Bhujwalla, Z.M., Glickson, J.D. Single scan in vivo lactate editing by selective multiple quantum coherence transfer. 12th Annual Scientific Meeting and Exhibition, Society of Magnetic Resonance in Medicine, New York, August 1993: p 420.
  95. Bhujwalla, Z.M., Shungu, D.C., He, Q., Wehrle, J.P., Glickson, J.D. Blood flow modifier mediated changes in tumor choline compounds detected in vivo by localized 1H NMR spectroscopy. 12th Annual Scientific Meeting and Exhibition, Society of Magnetic Resonance, New York, August 1993: p 986.
  96. Gillies, R.J., Liu, Z., Bhujwalla, Z.M. 31P NMR measurement of extracellular pH of tumors and tumor cells in site using 3-aminopropylphosphonate. 12th Annual Scientific Meeting and Exhibition, Society of Magnetic Resonance in Medicine, New York, August 1993: p 26330.
  97. He, Q., van Zijl, P.C.M., Shungu, D.C., Bhujwalla, Z.M., Glickson, J.D. Single scan in vivo lactate editing by selective multiple quantum coherence transfer. 12th Annual Scientific Meeting and Exhibition, Society of Magnetic Resonance in Medicine, New York, August 1993: p 420.
  98. Bhujwalla, Z.M., Shungu, D.C., He, Q., Wehrle, J.P., Glickson, J.D. Changes in Tumor Choline Compounds Induced by Nictotinamide Detected in vivo by 2-Dimensional1H NMR Spectroscopy. Proceedings of the Annual Meeting of the Radiation Research Society, Dallas, p. 131, 1993.
  99. Bhujwalla, Z.M., Stolk, J.A., Blackband, S.J., Shungu, D.C., Wehrle, J.P., and Glickson, J.S. Absolute blood flow in RIF-1 tumors measured in vivo by 1H/2H NMR spectroscopy. 14th Annual Meeting of the Radiation Research Society, Salt Lake City, 1992.
  100. Bhujwalla, Z.M., Shungu, D.C., Chatham, J.C., Wehrle, J.P. and Glickson, J.D. Glucose metabolism in RIF-1 tumors. 17th L. H. Gray Conference, Canterbury, 1992.
  101. Bhujwalla, Z.M., Blackband, S.J., Stolk, J.A., Shungu, D.C., Wehrle, J.P. and Glickson, J.D. Blood flow within RIF-1 tumors: A 1H/2H spectroscopic, imaging and histological study. 11th Annual Scientific Meeting and Exhibition, Society of Magnetic Resonance in Medicine, Berlin, August 1992.
  102. Forder, J.P., Bhujwalla, Z.M., Blackband, S.J., Chatham, J.C., Wehrle, J.P., Glickson, J.D. 13C and 1H spectroscopic and 1H imaging studies of a tissue-isolated perfused tumor model. 11th Annual Scientific Meeting and Exhibition, Society of Magnetic Resonance in Medicine, Berlin, August 1992.
  103. Bhujwalla, Z.M., Glickson, J.D. and Blackband, S.J. Magnetization transfer imaging at 4.7T of subcutaneous tumors and correlation with histology. 11th Annual Scientific Meeting and Exhibition, Society of Magnetic Resonance in Medicine, Berlin, August 1992.
  104. Shungu, D.C., Bhujwalla, Z.M., Aiken, N.A., Wehrle, J.P., and Glickson, J.D. Assignment of resonances in the 1H NMR spectra of subcutaneous EMT6/SF mammary adenocarcinoma tumors by 2D COSY analysis of tissue extracts. 11th Annual Scientific Meeting and Exhibition, Society of Magnetic Resonance in Medicine, Berlin, August 1992.
  105. Shungu, D.C., Bhujwalla, Z.M., Wehrle, J.P. and Glickson, J.D, Proton magnetic resonance spectroscopy of subcutaneous RIG-1 tumors during untreated growth and following treatment with 5-fluorouracil. 11th Annual Scientific Meeting and Exhibition, Society of Magnetic, Berlin, August 1992.
  106. Shungu, D.C., Bhujwalla, Z.M., Wehrle, J.P., Glickson, J.D. 1H magnetic resonance spectroscopic study of metabolic heterogeneity in subcutaneous RIF-1 tumor following acute blood flow reduction. 11th Annual Scientific Meeting and Exhibition, Society of Magnetic Resonance in Medicine, Berlin, August 1992: p 3507.
  107. Bhujwalla, Z.M., Shungu, D.C., van Zijl, P.C.M., Glickson, J.D. In vivo detection of 13C-glucose uptake and 13C-lactate efflux in a murine tumor by 1H{13C}NMR spectroscopy following intravenous Infusion of {1-13C} glucose. 11th Annual Scientific Meeting and Exhibition, Society of Magnetic Resonance in Medicine, Berlin, August 1992: p 3536
  108. Bhujwalla, Z.M., Blackband, S.J., Wehrle, J.P. and Glickson, J.D. Heterogeneity of the metabolic response of RIF-1 tumors to a vasoactive agent evaluated by 1-dimensional 31P chemical shift imaging. 7th International Conference on Chemical Modifiers of CancerTreatment, Clearwater, Florida, February 1991.
  109. Bhujwalla, Z.M., Shungu, D.C., Chatham, J.C., Wehrle, J.P., and Glickson, J.D. Glucose metabolism in RIF-1 tumors following blood flow reduction. 9th International Congress of Radiation Research, Toronto, July 1991.
  110. Bhujwalla, Z.M., Blackband, S.J., Chatham, J.C., Constantinidis, I.C., Shungu, D.C., Wehrle, J.P., Glickson, J.D. Manipulation of pH in RIF-1 tumors. 10th Annual Scientific Meeting and Exhibition, Society of Magnetic Resonance in Medicine, San Francisco, August 1991: p 612.
  111. Stolk, J.A., Bhujwalla, Z.M., Blackband, S.J., Shungu, D.C., Wehrle, J.P., and Glickson, J.D. Quantitative in vivo measurement of blood flow in RIF-1 tumors by 1H/2H NMR spectroscopy. 10th Annual Scientific Meeting and Exhibition, Society of Magnetic Resonance in Medicine, San Francisco, August 1991: p 984.
  112. Shungu, D.C., Bhujwalla, Z.M., Li, S.J., Rose, L.M., Wehrle, J.P.and Glickson, J.D. Absolute quantification of phosphorus metabolites in RIF-1 tumors in vivo at 11.7 T: A 31P-1H-2H ternuclear validation of the Thulborn-Ackerman method. 10th Annual Scientific Meeting and Exhibition, Society of Magnetic Resonance in Medicine, San Francisco, August 1991: p 982.
  113. Bhujwalla, Z.M., Blackband, S.J., Wehrle, J.P., and Glickson, J.D. The heterogeneity of metabolites and pH within RIF-1 tumors. 38th Annual Meeting of the Radiation Research Society, New Orleans, April 1990.
  114. Bhujwalla, Z.M., Blackband, S.J., Grossman, S., Wehrle, J.P., Eller, S. and Glickson, J.D. Heterogeneity of pH within RIF-1 tumors. 81st Annual Meeting of the American Association of Cancer Research, Washington, D.C., May 1990.
  115. Bhujwalla, Z.M., Blackband, S.J., Wehrle, J.P. and Glickson, J.D. Evaluation of the heterogeneity of the metabolic response of tumors to a vasoactive agent by 1-dimensional 31P chemical shift imaging. 9th Annual Scientific Meeting and Exhibition, Society of Magnetic Resonance in Medicine, New York, August 1990: p 822.
  116. Bhujwalla, Z.M., Shungu, D.C., Chatham, J.C., Wehrle, J.P. and Glickson J.D. The effects of blood flow manipulation on the glucose metabolism of RIF-1 tumors: An in vivo 13C and 31P NMR study. 9th Annual Scientific Meeting and Exhibition, Soiety of Magnetic Resonance in Medicine, New York, August 1990: p 1260.
  117. Blackband S.J., Bhujwalla, Z.M., Miller D., Wehrle, J.P., and Glickson, J.D. The correlation of 1-demensional 31P CSI spectra with heterogeneity in subcutaneously implanted RIF-1 tumors in mice. 8th Annual Scientific Meeting and Exhibition, Society of Magnetic Resonance in Medicine, Amsterdam, August 1989.
  118. Constantinidis, I., Bhujwalla, Z.M., Chatham, J.C., Wehrle, J.P., and Glickson, J.D. 13C and 31P NMR study of RIF-1 tumors following glucose administration. 8th Annual Scientific Meeting and Exhibition, Society of Magnetic Resonance in Medicine, Amsterdam, August 1989.
  119. Bhujwalla, Z.M., Tozer, G.M., Maxwell, R.J., Field, S.B. and Griffiths, J.R. The effect of a vasodilator hydralazine, on the vascular perfusion of tumors: A P-31 MRS study in vivo. 7th Annual Meeting of the Society of Magnetic Resonance in Medicine, San Francisco, August 1988.
  120. Williams, S.R., Bhujwalla, Z.M. and Proctor, E. Simultaneous measurement of flow and metabolism within tumors in vivo. 7th Annual Meeting of the Society of Magnetic Resonance in Medicine, San Francisco, August 1988.
  121. Bhujwalla, Z.M., Tozer, G.M., Maxwell, R.J. and Griffiths, J. R. An in vivo study of changes in tumor metabolism following radiation using P-31 magnetic resonance spectroscopy. 8th International Congress of Radiation Research, Edinburgh, July 1987.
  122. Bhujwalla, Z.M., Tozer, G.M., Maxwell, R.J. and Griffiths, J. R. The significance of changes in P-31 magnetic resonance spectra following radiotherapy in mouse tumors. 6th Annual Meeting of the Society of Magnetic Resonance in Medicine, New York, August, 1987.
  123. Bhujwalla, Z.M., Maxwell, R. J., Tozer, G.M. and Griffiths, J.R. 31P MRS monitoring of radiotherapy in mouse tumors. 5th annual Meeting of the Society of Magnetic Resonance in Medicine, Montreal, August 1986.

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