Research Projects

• ‘Multiparametric MRI in Breast Cancer’ (NIH / NCI (Jacobs, M.A., PI) 07/01/2004 - 06/30/2008, 1RO1 CA100184)
  
• ‘Proton MR Spectroscopic Imaging in Human Breast Cancer’ (NIH (Barker, P., PI) 10/1/01-3/31/05, 1R21 CA/RR91798 (Dual R21/R33)
  The goal of this project is the technical development of proton MR spectroscopy of the human breast to diagnose breast cancer. Dr. Jacobs is a co-investigator on this grant.
  
• ‘²³Na Imaging In Breast Cancer’(NIH / NCI (Ouwerkerk, R., PI) 09/15/03 – 08/31/05, 1R21 CA095907
  To develop a breast MR imaging protocol with improved specificity through the inclusion of ²³Na MRI. Dr. Jacobs is a co-investigator on this grant.
  
• ‘Interdisciplinary Small Animal Imaging for Oncology’(SAIRP (Pomper, M., PI) 07/01/01 - 06/30/06, R24 CA92871)
  The goal of this application is to expand our interdisciplinary small animal imaging program (pre-ICMIC) to include complementary imaging capabilities that will increase our understanding of cancer.

• 'Functional Imaging of the Metastatic Phenotype' (NIH (Bhujwalla, Z.M., P.I.) 04/01/97-03/31/07, 1R01 CA73850)
  In vivo and perfused cell studies to determine the role of physiological environment and vascularization in the metastatic spread of prostate cancer.

• Supplement to 'Functional Imaging of the Metastatic Phenotype' (NIH (Bhujwalla, Z.M., P.I.) 04/01/00-03/31/01, 3R01 CA73850-04S1)

• 'Hostile Environments Promote Invasion and Metastasis' (NIH (Bhujwalla, Z.M., P.I.) 07/01/99-06/30/04, 1R01 CA82337-01)
  The aim of these studies is to identify the interaction between the physiological environment and inflammatory signaling and vascularization in breast cancer invasion and metastasis and the ability of anti-inflammatory agents to prevent invasion and metastasis.

• ‘Imaging Lymphatic Clearance in Tumor Metastasis’ (NIH (Bhujwalla, Z.M., P.I.) 04/01/01 – 03/31/04, 1R01 CA90471)
  This application, written in collaboration with Dr. Michal Neeman (P.I. Subcontract, Weizmann Institute), is to understand the role of lymphangiogenesis in breast cancer metastasis.

• 'Imaging the Vascular and Metabolic Impact of Claudin-7, a tight junction protein, in transgenic human breast cancer models' (USAMRMC (Sukumar, S., P.I.) 07/01/01-06/30/04, DAMD17-01-10285)
  This application was funded to understand the effect of Claudin-7 on invasion, vascularization and metabolism.

• ‘Imaging the Role of MASPIN in Vascularization’ (NIH (Davidson, N.E., P.I.) 09/30/00-09/29/05, P50 CA88843)
  Pilot project funded on SPORE in Breast Cancer

• ‘Imaging Techniques to Examine Drug Delivery ’ (Avon Products Foundation (Artemov, D., P.I.) 10/01/01-09/30/03)
  

• ‘MR Molecular Imaging of Her-2/Neu Receptors with Targeted Nanoparticles’ (Susan G. Komen Breast Cancer Foundation (Artemov, D. P.I.) 11/01/01-10/31/03, IMG0100775)
  This grant was awarded for development of MR technique for in vivo detection of Her-2/Neu receptors and assessment of anti-Her-2/Neu therapy.

Completed Projects:

• 'Research Training in Oncology Imaging' (NIH Training Grant T32 CA09630 (Zerhouni, E.A., PI until 06/30/01; Bhujwalla, Z.M., PI from 07/01/01))
  Trainees co-mentored under this program are:
  Anne Ferguson (Sara Sukumar, Preceptor): from 09/30/1998 until 09/29/1999
  Mustafa Vali (Sara Sukumar, Preceptor): from 10/01/1998 until 09/30/2000
  Robert Delsite (Keshav Singh, Preceptor): from 10/01/1998 until 11/30/2000
  Michael Jacobs (Zaver M. Bhujwalla, Preceptor): from 01/01/2000 until 11/31/2001
  Paul Winnard (Zaver M. Bhujwalla, Preceptor): from 12/03/2001 until 12/02/2003
  Nicholas Geoffeney (Zaver M. Bhujwalla, Preceptor): from 09/02/2002 until 09/01/2003
• Multidisciplinary Functional Imaging of Cancer' (NIH (Bhujwalla, Z.M., P.I.) 07/01/00-06/30/03, 1P20 CA86346)
  This application was funded to establish a 'Pre-In vivo Cellular and Molecular Imaging Center'