Dr. Arvind P. Pathak

Instructor


Education

Professional Experience

Professional Honors and Awards

Membership in Professional Societies

Reviewing Activities

Publications

Oral Presentations

Presentations at Conferences


Keywords

Magnetic Resonance Imaging
Molecular Imaging
Tumor Angiogenesis
Lymphangiogenesis
Breast Cancer and Prostate Cancer
Invasion and Metastasis
Vascularization and Permeability
MRI Contrast Mechanisms

Research Area

Imaging Lymphatic Clearance in Tumor Metastasis


Education:

Institute

Degree

Year

Area of Study
Medical College of Wisconsin and Marquette University, Milwaukee, WI, USA
Ph.D.
2001
 Biophysics / Biomedical Engineering
University of Poona, Pune, India
B.E.
1993
 Industrial Electronics

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Professional Experience:

Date

Title

Affiliation
11/2003-present Instructor Division of MR Research, Dept. of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
12/2001-10/2003 Postdoctoral Research Fellow Division of MR Research, Dept. of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
06/1996-11/2001 Whitaker Foundation Doctoral Research Fellow Joint Functional Imaging Program: Biophysics Dept. of the Medical College of Wisconsin and Biomedical Engineering Dept. at Marquette University, Milwaukee, WI, USA
12/1994-05/1996 Research Assistant Dept. of Biomedical Engineering, Bioinstrumentation and Signal Processing Laboratory, Marquette University, Milwaukee, WI, USA
06/1994 - 12/1994 Research Assistant Laboratory of Sensory and Motor Performance, VA Medical Center, Milwaukee, WI, USA

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Professional Honors and Awards:

  • 2002 The Bill Negendank Award – First Place for “Outstanding Young Investigators in the Field of Cancer MR”, ISMRM

  • 2001 Publication Award, Medical College of Wisconsin Cancer Center Trainee Research Paper Competition

  • 1997 - 2000 Whitaker Foundation Functional Imaging Doctoral Fellowship, Dept. of Biomedical Engineering, Marquette University, Milwaukee, WI

  • 2000 Educational Stipends for Students and Postdoctoral Trainees, ISMRM, Travel Award

  • 1999 Educational Stipends for Students and Postdoctoral Trainees, ISMRM, Travel Award

  • 1998 Educational Stipends for Students and Postdoctoral Trainees, ISMRM, Travel Award

  • 1996 Student Stipend Award ­ Bioengineering Section of the American Society of Mechanical Engineering (ASME)

  • 1994 - 1996 Graduate Research Assistantship, National Science Foundation, Dept. of Biomedical Engineering, Marquette University, Milwaukee, WI

  • 1993 First Class, Industrial Electronics, University of Poona, India

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Membership in Professional Societies:

Reviewing Activities:

Publications:

  • Peer-reviewed Scientific Articles

    1. Pathak, A.P., Artemov, D., and Bhujwalla, Z.M. A Novel System for Continuous in Vivo Monitoring of Contrast Dynamics in a Mouse Tumor Model. Magnetic Resonance in Medicine, (in press), 2003.
    2. Glunde, K., Guggino, S.E., Solaiyappan, M., Pathak, A.P., Ichikawa, Y., and Bhujwalla, Z.M. Extracellular acidification alters lysosomal trafficking in human breast cancer cells. Neoplasia, 5(6): 533-545, 2003.
    3. Badruddoja, M.A., Krouwer, H.G.J., Rand S.D., Rebro, K.J., Pathak, A.P., and Schmainda, K.M. Anti-Angiogenic Effects of Dexamethasone in 9L Gliosarcoma Assessed by MRI Cerebral Blood Volume Maps. Neuro-Oncology, 5(4): 235-243, 2003 – Cover Article.
    4. Pathak, A.P., Rand, S. D., and Schmainda, K. M. The Effect of Brain Tumor Angiogenesis on the In Vivo Relationship Between the Gradient Echo Relaxation Rate Change (DR2*) and Contrast Agent (MION) Dose. Journal of Magnetic Resonance in Medicine, 18(4): 397-403, 2003.
    5. Biswal, B.B., Pathak, A.P., Ulmer, J.L., and Hudetz, A.G. Decoupling of the Hemodynamic and Activation-Induced Delays in fMRI. Journal of Computer Assisted Tomography, 27(2):219-225, 2003.
    6. Pathak, A.P., Schmainda, K.M., Ward, B.D., Linderman, J.R., Rebro, K.J., and Greene, A.S. MR-derived Cerebral Blood Volume Maps: Issues Regarding Histological Validation and Assessment of Tumor Angiogenesis. Magnetic Resonance in Medicine, 46(4):735-747, 2001.
    7. Donahue, K.M., Krouwer, H.G.J., Rand, S.D., Pathak, A.P., Marszalkowski, C S., Censky, S.C., and Prost, R.W.Utility of simultaneously acquired gradient-echo and spin-echo cerebral blood volume and morphology maps in brain tumor patients. Magnetic Resonance in Medicine, 43(6):845-853, 2000.
    8. Pathak, A.P., Silver-Thorn, M.B., Thierfelder C.A., Prieto T.E. A Rate Controlled Indentor for In Vivo Analysis of Residual Limb Tissues. IEEE Transactions on Rehabilitation Engineering, 6(1):12-20, 1998.

  • Papers presented at Symposia and Published in Journals or Books

    1. Pathak A.P., Artemov D., Jackson D.G., Dafni H., Neeman M., and Bhujwalla Z.M. Probing Intratumoral Lymphangiogenesis and Lymphatic Function Using Optical Imaging 2nd Annual Meeting of the Society for Molecular Imaging, San Francisco, CA, USA, August 15-18, 2003; published in: Molecular Imaging, 2(3):265, 2003.
    2. Raman V., Artemov D., Mironchik Y., Pathak A.P., and Bhujwalla Z.M. Combined Molecular and Functional Imaging Characterization of the Tumor Microenvironment 1st Annual Meeting of the Society for Molecular Imaging, Boston, MA, USA, August 24 - 26, 2002; published in: Molecular Imaging, 1(3):186, 2002.

  • Invited Review(s)

    1. Pathak, A.P., Gimi, B., Glunde, K., Ackerstaff, E., Artemov, D., and Bhujwalla, Z.M. Molecular And Functional Imaging Of Cancer: Advances in MRI and MRS Methods in Enzymology: Imaging (in press), v. 385, 2003.
    2. Pathak, A.P., Artemov, D., Solaiyappan, M., and Bhujwalla, Z.M. MRI may permit assessment of tumor growth processes. Diagnostic Imaging,25(4): 25-33, 2003.

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Invited Oral Presentations:

  • MRI and Spectroscopy Center, University of Kentucky College of Medicine, Nov 2003.
    Title of Talk: ‘Magnetic Resonance Imaging Of Cancer – “Angiogenesis, Lymphangiogenesis and Beyond.’
  • Dept. of Biomedical Engineering, Rutgers University, NJ, Dec 2002.
    Title of Talk: ‘Image Contrast In MRI- What Does It Mean For Imaging Cancer?’
  • Dept. of Radiology/Oncology, University of Medicine and Dentistry of New Jersey, NJ, July 23, 2001.
    Title of Talk: ‘The non-invasive in vivo assessment of brain tumore angiogenesis using magnetic resonance imaging.’
  • Lectures on Tumor Angiogenesis: Interview, Dept. of Radiology, Division of MR Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA, July 31, 2001.
    Title of Talk: ‘The assessment of brain tumor angiogenesis using susceptibility based functional mganetic resonance imaging.’

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Presentations at Meetings Published in Conference Proceedings:

Peer Reviewed Abstracts

  1. Pathak, A.P., Artemov, D., Jackson, D.G., Neeman, M., and Bhujwalla, Z.M. Intratumor and Intertumor Heterogeneity in Contrast Agent Kinetics as Assessed by Functional MRI - Initial Results with Implications for Metastasis. 11th Scientific Meeting & Exhibition of the International Society for Magnetic Resonance in Medicine, Toronto, ON, Canada, July 10-16, 2003.
  2. Bhujwalla, Z.M., Raman, V., Artemov, D., Mironchik, Y., Kollars, P., Pathak, A.P., and Solaiyappan, M. MRI of Prostate Tumors Overexpressing VEGF Exhibit Distinct Alterations Of Vascular Permeability. 11th Scientific Meeting & Exhibition of the International Society for Magnetic Resonance in Medicine, Toronto, ON, Canada, July 10-16, 2003.
  3. Schmainda, K.M., Rand, S.D., Joseph, A., Hanson, R., Ward, B.D., Pathak, A.P., Baddrudoja, M., and Krouwer, H.G. A Combined Gradient-Echo/Spin-echo DSC Method: A Surrogate Marker for Brain Tumor Histologic Grade and Angiogenesis in Patients. 11th Scientific Meeting & Exhibition of the International Society for Magnetic Resonance in Medicine, Toronto, ON, Canada, July 10-16, 2003.
  4. Schmainda, K.M., Rand, S.D., Joseph, A., Ward, B.D., Hanson, R., Pathak, A.P., Baddrudoja, M., and Krouwer, H.G. Dynamic Gradient-Echo and Spin-Echo Measurements of Tumor Blood Volume and Vascular Morphology Predict Tumor Grade in Patient’s with Brain Tumors. ISMRM Workshop on In Vivo Functional and Molecular Assessment of Cancer, Chaminade at Santa Cruz, CA, USA, October 19-21, 2002.
  5. Raman V., Artemov D., Mironchik Y., Pathak A.P., Bhujwalla Z.M. Combined Molecular and Functional Imaging Characterization of Tumor Hypoxia, Vascularization, and Metabolism. ISMRM Workshop on In Vivo Functional and Molecular Assessment of Cancer, Chaminade at Santa Cruz, CA, USA, October 19-21, 2002.
  6. Pathak, A.P., Artemov, D., Jackson, D.G., Neeman, M., and Bhujwalla, Z.M. Intratumor and Intertumor Heterogeneity in Contrast Agent Kinetics as Assessed by Functional MRI - Initial Results with Implications for Metastasis. ISMRM Workshop on In Vivo Functional and Molecular Assessment of Cancer, Chaminade at Santa Cruz, CA, USA, October 19-21, 2002.
  7. Pathak, A.P., Ward, B.D., Hudetz, A.G., Schmainda, K.M. A Novel Technique for Estimating the Susceptibility-Induced MR Signal For Arbitrary Microvascular Geometries: The Finite Perturber Method. 10th Scientific Meeting & Exhibition of the International Society for Magnetic Resonance in Medicine, Honululu, Hawai'i, USA, May 18-24, 2002.
  8. Pathak, A.P., Ward, B.D., Rebro, K.J., Schmainda, K.M. The Effect of Brain Tumor Angiogenesis on the In Vivo Relationship Between Contrast Agent (MION) Dose and the Gradient Echo Relaxation Rate Change (DR2*). 10th Scientific Meeting & Exhibition of the International Society for Magnetic Resonance in Medicine, Honululu, Hawai'i, USA, May 18-24, 2002.
  9. Biswal, B.B., Pathak, A.P. A Novel MR Brain Segmentation Technique Using Dynamic Susceptibility Contrast. 10th Scientific Meeting & Exhibition of the International Society for Magnetic Resonance in Medicine, Honululu, Hawai'i, USA, May 18-24, 2002.
  10. Quarles, C.C., Pathak, A.P., Ward, B.D., Rebro, K.J., Schmainda, K.M. Reliability of Measuring Tumor Perfusion using Dynamic Susceptibility Contrast MRI: The Influence of Vascular Structure and Imaging Technique. 10th Scientific Meeting & Exhibition of the International Society for Magnetic Resonance in Medicine, Honululu, Hawai'i, USA, May 18-24, 2002.
  11. Schmainda K.M., Rand S.D., Badruddoja M., Pathak A.P., Rebro K.J., Krouwer H.G. Dexamethasone Selectively Treats Tumor Vasculature as Demonstrated By Simultaneous GE and SE rCBV Measurements. 10th Scientific Meeting & Exhibition of the International Society for Magnetic Resonance in Medicine, Honululu, Hawai'i, USA, May 18-24, 2002.
  12. Pathak, A.P., Schmainda, K.M., Ward, B.D., Linderman, J.R., Rebro, K.J., and Greene, A.S. MR-Derived Cerebral Blood Volume Maps: Issues Regarding Histological Validation and Assessment of Tumor Angiogenesis. 9th Scientific Meeting and Exhibition of the International Society of Magnetic Resonance in Medicine, ISMRM-ESMRB Joint Annual Meeting, Glasgow, April 21 - 27, 2001.
  13. Pathak, A.P., Schmainda, K.M., Ward, B.D., Rebro, K.J., and Rand, S.D. Assessing Tumor Angiogenesis with Dynamic Susceptibility Contrast fMRI: Which Morphologic Correlates Are Relevant? 9th Scientific Meeting and Exhibition of the International Society of Magnetic Resonance in Medicine, ISMRM-ESMRB Joint Annual Meeting, Glasgow, April 21 - 27, 2001.
  14. Schmainda, K.M., Pathak, A.P., Badruddoja, M., Rand, S.D., Rebro, K.J., Krouwer, H.G. Effects of Dexamethasone Treatment on Dynamic Susceptibility CBV Measurements in a Rat Brain Tumor Model. 9th Scientific Meeting and Exhibition of the International Society of Magnetic Resonance in Medicine, ISMRM-ESMRB Joint Annual Meeting, Glasgow, April 21 - 27, 2001.
  15. Badruddoja, M.A., Krouwer, H.G., Schmainda, K.M., Rand, S.D., Rebro, K.J., Pathak, A.P., Marszalkowski, C.S. Dexamethasone Decreases Relative Cerebral Blood Volume (rCBV) and Vessel Diameter in 9L Gliosarcoma. 6th Annual Meeting of Society for Neuro-Oncology, Washington, DC, November 15-18, 2001
  16. Rand, S.D., Donahue, K.M., Krouwer, H.G., Badruddoja, M., Prost, R.W., Pathak, A.P., Kim, Y.R., Marszalkowski, C. S.Magnetic Resonance Markers of Neoplastic Angiogenesis in the Adult Brain: Works in Progress. Angiogenesis and Cancer: From Basic Mechanisms to Therapeutic Applications (organized by AACR), Traverse City, Michigan, October 11-15, 2000.
  17. Pathak, A.P., Linderman, R.J., Xu, H., Ward, B.D., Greene, A.S. and Donahue, K.M. Characterization of DR2*/DR2 for the Evaluation of Angiogenesis Induced Changes in Vascular Morphology. 8th Scientific Meeting and Exhibition of the International Society of Magnetic Resonance in Medicine, Denver, Colorado, April 1 - 7, 2000.
  18. Biswal, B.B., Pathak, A.P., Ward, B.D., Ulmer, J.L., Donahue K.M., and Hudetz A.G. Decoupling of the Hemodynamic Delay from the Task-Induced Delay in FMRI. NeuroImage - 6th Annual Meeting of the Organization for Human Brain Mapping 2000 Meeting, 663, 2000.
  19. Biswal, B.B., Pathak, A.P. A Novel MR Brain Segmentation Technique Using Dynamic Susceptibility Contrast. 8th Scientific Meeting and Exhibition of the International Society of Magnetic Resonance in Medicine, Denver, Colorado, April 1 - 7, 2000.
  20. Biswal, B.B., Pathak, A.P., Ward, B.D., Ulmer, J.L., Donahue K.M., and Hudetz A.G. Decoupling of the Hemodynamic Delay from the Task-Induced Delay in FMRI. 8th Scientific Meeting and Exhibition of the International Society of Magnetic Resonance in Medicine, Denver, Colorado, April 1 - 7, 2000.
  21. Pathak, A.P., Donahue, K.M. The Utility of the Sequential Contrast Agent Protocol in Assessing Changes in Relative Cerebral Blood Volume. 7th Scientific Meeting and Exhibition of the International Society of Magnetic Resonance in Medicine, Philadelphia, May 22 - 28, 1999.
  22. Donahue, K.M., Pathak, A.P. Utility of Acquiring Vascular Blood Volume, Permeability and Morphology Information from Dynamic Susceptibility Contrast Agent Studies in Patients with Brain Tumors.7th Scientific Meeting and Exhibition of the International Society of Magnetic Resonance in Medicine, Philadelphia, May 22 - 28, 1999.
  23. Pathak, A.P., Donahue, K.M. The Effect of Sequential Contrast Agent Studies on the Assessment of Relative Cerebral Blood Volume. 6th Scientific Meeting and Exhibition of the International Society of Magnetic Resonance in Medicine, Sydney, Australia, April 18 - 24, 1998.
  24. Donahue, K.M., Rand, S., Pathak, A.P. Evaluation of Human Brain Tumor Angiogenesis using Simultaneously Acquired Gradient Echo and Spin Echo EPI during Dynamic Susceptibility Contrast. 6th Scientific Meeting and Exhibition of the International Society of Magnetic Resonance in Medicine, Sydney, Australia, April 18 - 24, 1998.
  25. Pathak, A.P., Silver-Thorn, M.B. Design of a Rate Controlled Indentor for In Vivo Analysis of Residual Limb Tissues. Advances in Bioengineering, Winter Annual Meeting of the ASME Bioengineering Division, Atlanta, GA, 1996.
  26. Pathak, A.P., Silver-Thorn, M.B. An Embedded (PC-Based) Tissue Testing System for In Vivo Analysis of Residual Limb Tissues. Annual Fall Meeting of Biomedical Engineering Society ( BMES), The Pennsylvania State University, PA, October 3-6, 1996.

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last updated on 01/22/2004
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